Thymoproteasome bias

A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.

The Psmb11-encoded β5t subunit of the thymoproteasome, which is specifically expressed in cortical thymic epithelial cells (cTECs), is essential for the optimal positive selection of functionally competent CD8+ T cells in mice. Here, we report that a human genomic PSMB11 variation, which is detectable at an appreciable allele frequency in human populations, alters the β5t amino acid sequence th...

Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.

Cortical thymic epithelial cells (cTECs) express a unique thymoproteasome subunit-β5T that plays an essential role in the development of CD8 T cells. In contrast, the immunoproteasome subunit-β5i is expressed in other thymic antigen-presenting cells (APCs). The thymoproteasome may generate peptides that are specialized for positive selection, or it may simply serve to generate peptides that are...

A Comparison of the Effectiveness of Cognitive Bias Modification in Real and Placebo Conditions on Attentional Bias and Approach Bias in Opium Abusers

Background & Aim: Inability to control drug use is considered a core aspect of drug dependency. Part of this inability is due to cognitive biases resulting from individuals’ constant usage of drugs. The aim of the present study was to compare the effectiveness of cognitive bias modification in real and placebo conditions on attentional bias and approach bias in opium abusers. Methods: This stud...

The Effect of Cognitive Bias Modification in the Attention Bias of Students With Test Anxiety

Abstract Introduction: Many of the students chr('39')educational problems, including academic failure and maladaptive behaviors, stem from exam anxiety caused by studentschr('39') cognitive bias. Cognitive bias modification can reduce attention biases students to be negative. Therefore, the purpose of the present study was to investigate the effectiveness of cognitive bias modification interven...

The bias bias